Naturally arising human CD4 T cells that recognize islet autoantigens and secrete IL-10 regulate pro-inflammatory T cell responses via linked suppression
نویسندگان
چکیده
Timothy I.M. Tree, Jennifer Lawson, Hannah Edwards, Ania Skowera, Sefina Arif, Bart O. Roep and Mark Peakman Department of Immunobiology, King’s College London, Guy’s Hospital, London SE1 9RT, UK. Department of Immunohaematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. 3 NIHR Biomedical Research Centre at Guy’s & St Thomas’ NHS Foundation Trust and King’s College London
منابع مشابه
Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression
OBJECTIVE Regulatory T-cells (Tregs) recognizing islet autoantigens are proposed as a key mechanism in the maintenance of self-tolerance and protection from type 1 diabetes. To date, however, detailed information on such cells in humans, and insight into their mechanisms of action, has been lacking. We previously reported that a subset of CD4 T-cells secreting high levels of the immunosuppressi...
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تاریخ انتشار 2010